At Week 26, treatment with tesamorelin resulted in a reduction from baseline in mean trunk fat of 1.0 kg in Study 1 and 0.8 kg in Study 2, respectively (compared with an increase of 0.4 kg in Study 1 and of 0.2 kg in Study 2, respectively, in patients receiving placebo)
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GLP-1 receptor is expressed in several regions of the endocrine pancreas, gastrointestinal tract, lungs, heart, kidneys, and brain (18), and GLP-1 RAs is a half-life prolonging GLP-1 with stronger resistance to the degradation of dipeptidyl peptidase-4 (DPP-4)
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