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The most compelling candidates address multiple mechanisms simultaneously, which is why they show stronger results than compounds targeting a single pathway
No accumulation effects or delayed toxicity have been observed in controlled studies
doi: 10.7314/apjcp.2014.15.13.5187 83 OGradyTJKitaharaCMDiRienzoAGGatesMA
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One could speculate that a key treatment strategy for progressive MS could involve targeting CNS-resident B cells, not aiming to suppress their traditional immunological (mis)behavior, but instead to quell a yet-to-be-discovered unconventional action, possibly related to secretion of an MS-specific myelin toxin into the CSF
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