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AOD-9604 and GLP-1 agonists like Semaglutide or Tirzepatide work through fundamentally different mechanisms with very different efficacy profiles

Analysis of the GSTF8-L and GSTF8-S proteins demonstrated that GSTF8-L is solely targeted to plastids, whereas GSTF8-S is cytoplasmic (Thatcher et al., 2007)