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Data and safety monitoring board Study data and safety will be monitored by a DSMB that is independent of the Sponsor, funder (BARDA), and Investigators

01 Month 1 Calibration Initial protocol introduction

Both drugs affect different physiological systems and can influence appetite, cardiovascular function, and metabolic processes in distinct ways

However, they can cause side effects such as diarrhea, nausea, vomiting, dizziness, and headaches and many patients quickly regain much of the weight they have lost after they stop taking the medication

Chuang et al

Further, 2/3 of patients relapse within the first year in abstinence-based treatment models 3