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Semaglutide for weight loss should be used in addition to a reduced calorie diet and increased physical activity, the FDA says.

It reaches a steady level after about four to five weeks of daily dosing, because semaglutide has a half-life of around a week and builds up gradually

Oral semaglutide ($289/mo at PlexusDx) activates the same GLP-1 receptors and causes constipation through the same mechanism as injections

Exceeding recommended limits or using these peptides for extended periods may increase the risk of adverse effects

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We understand that patients often have questions about the differences between Semaglutide GLP-1 and Ozempic or whether they can safely switch between these treatments