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Vitamin B12 is essential for many bodily functions, including energy production, mood regulation, and red blood cell formation

And supplements marketed as boosting GLP-1 levels lack clinical evidence that they work in humans, at least by any measure that parallels the effects of prescription GLP-1 drugs, said Pieter Cohen, an associate professor of medicine at Harvard Medical School

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doi: 10.1038/jcbfm.2015.17 84 LarssonMLietzauGNathansonDstensonCGMallardCJohanssonMEet al

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Thus, in perfect agreement with the recent ADA-EASD consensus report [6], we also encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with established ASCVD (coronary artery disease, cerebrovascular disease, or peripheral arterial disease) or multiple risk factors for ASCVD (i.e., age 55 years, obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria) whose HbA1c remains suboptimal despite initial treatment with only one of these agents