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By doing so, it may reverse aging effects, improve tissue regeneration, enhance cognitive function, and promote overall longevity

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(2018, PLOS ONE ): transdermal dihydroberberine (a chemically modified form) applied in a pharmaceutical-grade cream with penetration enhancers achieved roughly 7x higher bioavailability than oral berberine in rats

First, temperature

The box plots centre line represents the median, with the lower and upper boundaries indicating the first and third quartiles, and whiskers extend 1.5 times the IQR from the boundaries