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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and in those with serious hypersensitivity to tirzepatide or its excipients
This is a theoretical concern and not a commonly reported clinical side effect with standard doses
However, some peptides are extremely unstable and will lose their potency very quickly after reconstitution
However, the consistency of the step-up pattern across sequential generations of compounds (single dual triple agonist) has generated significant research interest in the triple-agonist mechanism
Statements Author contributions LC contributed in collecting bibliography, in writing the manuscript, and in conceiving and creating the figures
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