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Writing to investors on Thursday, analysts at William Blair called this outcome underwhelming. Without demonstrating significant fibrosis improvement, they added, what makes pemvidutide different from other similar assets is unclear. While the Phase IIb IMPACT study met the MASH [metabolic dysfunction-associated steatohepatitis] resolution endpoint, we believe investors are considerably more interested in the other primary endpoint of fibrosis improvement, which correlates with liver failure, death and progression to cirrhosis or hepatocellular carcinoma, according to the analysts

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This seemingly paradoxical finding reflects enhanced insulin sensitivity

Semaglutide works by delaying stomach emptying and signaling the brain to feel full faster, naturally reducing food intake

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