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Therefore, monitoring of the platelet count and serum potassium concentrations are recommended during therapy

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[2] Pharmacokinetic studies demonstrate rapid systemic distribution with peak plasma levels occurring within 30-60 minutes of intramuscular injection, followed by extensive hepatic storage and enterohepatic recycling

Hydroxocobalamin is preferred because it binds more tightly to serum proteins, creating a depot effect that allows slower release and longer duration of action