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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025

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Diabetes Complic

Potential benefits of MOTS-c: Improved insulin sensitivity Better glucose control Increased exercise capacity Enhanced mitochondrial function Improved metabolic flexibility Unlike Semaglutide or Tirzepatide, MOTS-c does not primarily work by reducing appetite

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Understanding how GLP-1 medication influences these pathways can provide insights into its effectiveness in suppressing appetite and aiding weight loss