GLP-1 is a hormone produced naturally in the body that helps regulate appetite, food intake, and glucose levels by working on both the gut and the brain
That's the science
Alternative medication classes should be considered if GLP-1 therapy proves intolerable: SGLT2 inhibitors (such as dapagliflozin, empagliflozin) for type 2 diabetes, which work via a completely different mechanism and rarely cause gastrointestinal side effects DPP-4 inhibitors (such as sitagliptin, linagliptin), which enhance endogenous GLP-1 activity more gently Metformin remains first-line for type 2 diabetes, though it can also cause gastrointestinal side effects Orlistat for weight management, though this also has gastrointestinal side effects of a different nature For weight management specifically, NICE recommends a comprehensive approach including dietary modification, increased physical activity, and behavioural interventions, with or without pharmacotherapy
How does absorption align with my care plan goals
However, it is important to note that GLP-1 injections are not suitable for everyone
doi: 10.1007/s40261-021-01038-1 10 SuwannasomNKaoIPruAGeorgievaRBumlerH
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