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In conclusion, as shown in Fig S1, the activation of eNOS by BPC 157 is mediated through multiple regulation processes including the promotion of VEGFR2 activation and endocytosis, the activation of positive regulator AKT, the reduction of the interaction of negative regulator Cav-1 with eNOS

Similar anti-metastatic effects have been noted for caffeic and gallic acids, which downregulate MMP and VEGF expression in melanoma and breast cancer cells (5, 126)

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doi: 10.3390/cancers13112512 88 CroweSE