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Under the JHU Agreement, prior to the Kala Agreement renegotiation described below, we were responsible for paying each developmental milestone payment for the first three products to achieve such milestone, and milestones for the second and third products are reduced by 50%

And with oral formulations from Novo Nordisk and Eli Lilly expected within the next 12 to 18 months, utilization is likely to increase further as the injection barrier drops

doi: 10.1016/j.numecd.2011.08.010 242

Some are involved in growth hormone signaling

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Average expected weight loss for those who followed the titration protocol was 5.8 lbs