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Several recent CVOTs have shown that GLP-1RAs can reduce the decline of estimated GFR (eGFR) and delay the onset of the occurrence of proteinuria in patients with T2DM [4, 22, 26, 46, 47]

human GLP-1RA based analogues), the receptor activation is different between short-acting (on/off) and long-acting (continuous) compounds

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Chronic diarrhea can also lead to inflammation and increased pressure in the anal area