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Research approaches include exercise testing protocols (treadmill, swim tests), muscle biopsies with metabolic analysis, non-invasive spectroscopy (31P-MRS for energetics), isolated muscle preparations, and satellite cell culture for regeneration studies

After activation by GLP-1, the endogenous transcription factor CREB (cAMP response element-binding protein) binds to the CRE response element, inducing transcription of the luciferase reporter

Diabetes 70 , 27062719 (2021)

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For example, the silent information regulator 1 (SIRT1), a NAD + -dependent protein deacetylase, functions as a key upstream regulator for LKB1/AMPK signaling in the liver 50