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Our brain requires a lot of energy to function, which is produced by the mitochondria, the "energy factories" of cells

Grover M, Bernard CE, Pasricha PJ, et al

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In all four major trials, despite substantial statistical power to detect a clinically meaningful treatment effect, the administration of sitagliptin, saxagliptin, alogliptin and omarigliptin did not reduce the combined risk of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke [47,48,49,50]