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These irregular patterns were unlikely to be associated with dilution of intracellular contents by the pipette solution, as identical results could be detected using loose patch-clamp to rule out cell dialysis artefacts 19 (Fig
Acta 1828, 20022006
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CASE STUDY ANSWER Sixty-seven percent of total standard digoxin clearance is renal, so the standard renal clearance is 0.67 9 L/h = 6 L/h/70 kg with creatinine clearance of 100 mL/min and nonrenal clearance is (1 0.67) 9 L/h = 3 L/h/70 kg (see Table 31 for standard pharmacokinetic parameters)
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