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178,180 The PI3K/Akt signaling pathway, activated by GLP-1, plays a vital role in maintaining pancreatic -cell survival and promoting their proliferation

Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models along with Kaplan-Meier survival analyses to estimate outcomes at the end of 1, 3, 5, and 7 years

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Among its most impressive historical sites are Nicopolis ad Istrum, Perperikon, Pliska, and Preslavformer capitals where traces of Thracian, Roman, and medieval Bulgarian culture converge

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