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using the standard formula/program [Citation19]

DNA methylation typically represses gene expression by interfering with transcriptional activity [178], while histone modifications remodel chromatin architecture to either facilitate or restrict transcription factor access to DNA [179]

In ME/CFS, this protective mechanism is severely compromised

omega-3 fatty acids exert more complex bioactive effects, including down-regulation of inflammatory cytokines and also serve as precursors of essential lipid mediators, in particular specialized pro-resolving mediators (SPMs) such as resolvins, protectins and maresins

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The O/PEs were stored for a maximum of 1 week in 1% PFA at 4 C