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The medication is usually started at a low dose (0.25 mg weekly for Ozempic, 0.25 mg for Wegovy) and titrated upward every four weeks to minimize gastrointestinal side effects

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Effect pattern : Effects are immediate but can build subtly with repeated use

GLP-1 medications can cause mild dehydration as a side effect, and alcohol compounds this risk

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This work was supported by the Funds of National Natural Science Foundation of China (82060728), Guizhou Provincial Science and Technology Department (MS [2025-380], Thousand Talents Program), Talents of Guizhou Science and Technology Platform [2021]1350-009, Zunyi Science and Technology Bureau (HZ-2023-173, HZ-2023-09, [2024] No