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In SURMOUNT-4, adults who had lost an average of 20.9% on Mounjaro then switched to placebo regained 14% of their starting weight over the following year, retaining only about a third of the weight loss theyd initially achieved

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In one study of 3,127 adults with obesity but not diabetes, those taking the highest dose lost an average of 27 pounds, or 12.4 % of body weight, over 72 weeks

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Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine

This was 494 out of 600 initial participants