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N Engl J Med (2022) 387:20516

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Report any serious or unexpected side effects to your healthcare provider and consider reporting to the FDA MedWatch program (www.fda.gov/medwatch)

An unexpected finding in our studies was the loss of improved lipid tolerance in Dpp4 EC/ mice, with or without coadministration of sitagliptin, following BMT, implying an interaction between bone marrowderived cells and the metabolic actions emanating from the reduction of DPP-4 activity in endothelial cells

Feb 11 2020;10(2)doi:10.3390/metabo10020064

Clinical trials have tested weekly doses ranging from 1 mg to 12 mg, with gradual titration used to improve tolerability and minimize gastrointestinal side effects