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Maussang and co-workers showed in an in vitro model that GSH-PEG liposomes penetrated the BBB via a carrier-mediated active transcytosis mode and the penetration was increased in proportion to the amount of GSH-PEG used [41]

Notwithstanding about the promising mechanisms of action, translation to patients is limited by bioavailability and pharmacokinetic issues, inter-subject variability and possible interactions with other chemotherapeutic agents or endocrine therapies highlighting the need for well-conducted randomised controlled trials and PKPD studies (248)

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Ferroptosis may have a double-edged effect on the development of endometriosis