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This selectivity profile matched GHRH, which also does not stimulate the hypothalamic-pituitary-adrenal (HPA) axis

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This damage can result in mutations within oncogenes such as RAS and MYC, as well as tumor suppressor genes like p53 and PTEN, thereby fostering genomic instability and malignant transformation [31, 32]

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Involved in cellular signaling and regulating calcium levels, CD38 degrades NAD + , using it as a co-substrate for its enzymatic activity 135,136

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