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People with kidney disease, low blood pressure, a history of kidney stones, or those taking specific medications may experience adverse effects

In fiscal year 2024, GLP-1s cost Connecticuts Medicaid program $85 million, after factoring in rebates, which amounted to 35% of the entire Medicaid pharmaceutical budget for the year

A post-hoc factorial analysis showed a 4.0% difference in body fat mass and a 2.4% difference in waist circumference

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However, adverse events, particularly nausea and digestive symptoms, were more common among participants taking GLP-1 drugs, and some stopped treatment due to side effects