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Experimental or investigational
Burak Altintas, MD, an orthopedist with UTMB, who was not involved in this study, further highlighted the following limitations of the research: The limitations include retrospective design and likely residual confounding despite matching as fracture risk is influenced by many variables that are not reported [] Further, the comparison group is heterogeneous, combining another GLP-1 receptor agonist (dulaglutide) with two mechanistically different weight-loss medications
Disease progression in this group of patients was found to be much slower, based on the annualized average increase of disability on the Unified Parkinsons Disease Rating Scale (UPDRS) score a measure of Parkinsons disability
We thank Daniel Drucker and Anthony Gramolini (Toronto, Canada) and Gary Lopaschuk (Edmonton, Canada) for helpful discussions and Daniel Drucker for providing the Glp1r / mice
The FDA labeling for all semaglutide formulations notes that GLP-1 receptor agonists delay gastric emptying, which could affect the absorption of oral medications
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