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Always use methylcobalamin, not cyanocobalamin, as methylcobalamin is pre-activated and immediately available for your body to use, especially important if you have MTHFR genetic variations or methylation issues
Vitamin B12 injections can last about a week but varies from patient to patient
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Pharmacy Compounding Advisory Committee Meeting Briefing Materials on AOD-9604
Published human trials mainly studied oral and intravenous forms, so subcutaneous amounts come from community practice rather than an approved clinical protocol
Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug
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