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Microglia can be artificially activated by LPS, which induces a switch from a protective to pro-inflammatory state with the production of IL-12, TNF, NO, superoxide anions, and peroxynitrite (H 2 O 2 ), causing motor neuron degeneration and exacerbation of disease progression in fALS mice [124126]
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Therefore, maintaining consistent storage conditions remains critical for both peptides and reconstitution solutions
Yu, Danxia et al
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