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While the biological rationale is compelling, definitive proof that GLP-1 medications prevent or treat Alzheimer's disease in humans remains lacking

GLP-1 patches produce 32% higher drug exposure in women compared to men, potentially affecting efficacy and side effects

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Experimental medicine studies that incorporate the measurement of relevant biomarkers have served to validate measures of cognition and described the link between insulin and neurodegenerative disorders,40 and may provide further useful data to fill the translational gap from animal to human studies behind the putative neuroprotective mechanisms of action of GLP-1RAs (see figure 1 and the Mechanisms of neuroprotection section)

10.3109/13880209.2014.993041 Pharm