In the gastrointestinal tract, GLP-1 delays gastric emptying through vagal activation and effects on smooth muscle, increases beta cell proliferation and survival as well as glucose-dependent insulin secretion, suppresses glucagon secretion, and reduces hepatic fat accumulation through fatty acid oxidation as well as hepatic gluconeogenesis [43]
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La prdida de peso es menor al 5% despus de 12 semanas en la dosis de mantenimiento de Wegovy (2.4 mg), lo que puede indicar la necesidad de reevaluar el plan de tratamiento