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In this experiment, the high protein diet can promote intestinal secretion of GLP-1, improve FGF21 resistance, upregulate LKB1 to activate the AMPK pathway, downregulate the expression of SERBP-1c mRNA and protein in the liver, and ultimately inhibit liver lipid synthesis [50]

Elevated baseline homocysteine (above 15 mol/L) contraindicates methionine supplementation until the underlying cause is addressed

Why it matters: Unlike CRP which reflects whole-body inflammation, calprotectin is gut-specific

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