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Early human studies demonstrated modest weight loss and appetite suppression, but development was curtailed due to concerns regarding glucagon-mediated hyperglycemia and cardiovascular effects

In some of the large-scale clinical studies evaluating the safety of GLP-1RAs against CV disease, the effect on kidneys was evaluated as a secondary endpoint

Nanoparticles exhibit the distinct advantage of traversing biological barriers to access specific sites, thereby facilitating direct interactions with molecular targets (e.g., DNA, proteins) within the blood, organs, tissues, or cells [7]

Cell 35, 427440