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Three consecutive prolines at positions 35 (Pro-Pro-Pro) and an additional proline at position 8 create local conformational rigidity through the unique angle constraints of pyrrolidine-containing residues

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Mass spectral data corroborated the identity of QR (Figure 2D), consistent with literature reports (Figure 2E ( To assess the efficacy of QR, we evaluated its effects on METH-induced hepatocellular damage by MTT assay (Figure 1G)