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Ferroptosis: when metabolism meets cell death
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Beyond its established connections with upregulated lysosomal activity, glutaminolysis, and tricarboxylic acid cycle function, ferroptosis can transition to an apoptotic phenotype when driven by intense endoplasmic reticulum stress and a metabolic shift favoring phosphatidylcholine over phosphatidylethanolamine (30)
Our underlying hypothesis was [that] if we can suppress peripheral inflammation, we will have a beneficial impact on cognition, explained Dr
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