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In insulin-sensitive tissues, oxidative stress interferes with insulin receptor signaling through modification of critical cysteine residues and activation of stress kinases
Further analyses show that O 3 exposure resulted in a twofold increase in the concentration of oxidized glutathione (Figure 1, Panel B) such that the ratio of total to oxidized glutathione decreased by 50% in the presence of 350ppb ozone (Figure 1, Panel C)
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