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Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs

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Underreported effect sizes and industry-funded trial bias affect the literature on both sides

doi: 10.1038/s12276-022-00736-w 89 YamazakiTHannaniDPoirier-ColameVLadoireSLocherCSistiguAet al