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The results have been striking: GHK-Cu has been shown to modulate the expression of more than 4,000 human genes, with the net effect being a return toward expression patterns associated with younger, healthier tissue.6 The pathways most consistently affected include antioxidant defense (upregulation of catalase, superoxide dismutase, and glutathione synthesis), DNA damage repair, extracellular matrix remodeling, and anti-inflammatory signaling

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However, Eggers test detected a significant risk of publication bias in MCI brain GSH literature (bias [95%CI] = 11.28 [20.6, 1.95], p =0.03) and AD blood GSH literature (bias [95%CI] = 5.18 [9.96, 0.40], p =0.035)