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The use of assisted reproductive technologies (ART) such as in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) can bypass some of the natural selection mechanisms that would prevent sperm with damaged DNA from fertilizing an egg, potentially leading to long-term consequences for the offspring

This review highlights NAD+ as a central regulator of cellular metabolism and stress responses, demonstrating that disruptions in NAD+ balance contribute to aging, metabolic disease, cancer, and neurodegeneration

Nothing here is medical, dosing, or therapeutic guidance

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doi: 10.1186/s12862-018-1214-1 48 NunesSCRamosCLopes-CoelhoFSequeiraCOSilvaFGouveia-FernandesSet al