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4 Molecular mechanisms of drug resistance in Leishmania 4.1 Mechanism underlying antimony resistance in Leishmania One of the primary mechanisms of antimony resistance in Leishmania is the reduced uptake of the drug by the parasite

RNA and protein analyses showed that NRF2 silencing by sh NRF2 significantly decreased (Fig

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This genomic flexibility, coupled with specific mutations in drug targets, overexpression of efflux transporters, and alterations in sterol biosynthesis pathways, enables Leishmania to withstand various therapeutic interventions and develop resistance to multiple drugs

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It plays a critical role in: Red blood cell production: Ensuring oxygen is efficiently transported throughout the body