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Unlike GHRP-2 and GHRP-6, which can elevate cortisol, prolactin, and acetylcholine levels, ipamorelin has been shown in animal studies to have no significant effect on adrenocorticotropic hormone (ACTH), cortisol, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or prolactin release

For example, methapyriline increases liver weight and the number of hepatocyte mitochondria in treated mice, with development of hepatotoxicity and liver neoplasia probably secondary to oxidative damage (Powell et al

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doi:10.1191/0748233702th157oa

doi:10.1016/j.lfs.2006.11.036 34

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