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In contrast, obesity reduces the expression of KLB in subcutaneous and visceral adipose tissue ( As an endocrine factor, FGF21 has been shown in preclinical models to exert effects in diverse tissues beyond liver, including adipose tissue, pancreas, skeletal muscle, and the central nervous system

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Importantly, this inhibition may not affect the antioxidative properties of FOXO4

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The information presented here is based on publicly available clinical trial data and is subject to change as new research becomes available

The TGA has previously warned consumers to steer clear of the drug due to its serious side effects that can be very damaging to your health