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Most patients begin at 0.25 mg once weekly, then progress through 0.5 mg, 1.0 mg, and potentially 1.7 mg or 2.4 mg based on clinical response and tolerability

The only active comparator ever used against cagrilintide monotherapy was liraglutide 3.0 mg in a Phase 2 study not tirzepatide so every ranking of the two is cross-trial inference across different populations and endpoints

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Instead of asking 'why not stack them,' the question becomes 'what specific outcome justifies adding a second compound with incomplete human safety data?' For research exploring maximal metabolic intervention where single-agent tirzepatide has plateaued, the stack may be defensible