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The 2.4-milligram dose was also effective, helping participants lose an average of 15.6% of their weight

Current studies suggest that peripherally administered GLP-1RA has low concentrations in the cerebrospinal fluid, and higher doses or improved delivery systems (e.g., nanoparticles, liposome encapsulation) may be needed to increase brain exposure

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Both agents provided clinically meaningful reductions in HbA 1c (2.6 mmol/mol [0.2%] with SGLT2i and 5.4 mmol/mol [0.5%] with GLP-1 RA)