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Co-loading tannic acid (TA) and kartogenin (KGN) into PMI produced the final hydrogel (PTK)

At 2mg/session weekly: 5 sessions = ~1.25 months

3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%

They also reduced catabolic enzyme activity and promoted anabolic matrix formation, consistent with the anti-catabolic and anabolic actions described in preclinical OA models