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Co-targeting the GLP-1R and GcgR for obesity treatment Unimolecular GLP-1R/GcgR co-agonists for obesity treatment The search for single molecules and, with recently developed high-tech approaches, single mechanisms for treatment of obesity is ongoing
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By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)
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