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For fifteen years, it was whether GLP-1 receptor activation could protect neurons, and the preclinical answer was a repeated yes

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10.22038/IJBMS.2022.65350.14384 110 LeffJ

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Deficiency in microbes of the gut microbiota impairs locomotion by increasing levels of the gut hormone GLP-1

Additionally, a compound called 8-epidiosbulbin E acetate, obtained from the plant Dioscorea bulbifera , is used as a plasmid-curing agent