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Analytica chimica acta 809, 174182 (2014)
American Journal of Applied Sciences
The recent discovery of the small molecule N6F11, which binds the tripartite region of Trim25 and promotes proteasome-degradation of GPX4 in pancreatic cancer cells, while sparing immune cells and the anti-tumoral response of the microenvironment, could represent a major clinical breakthrough for the use of GPX4 inhibitor/degrader [61]
In cultures of human THP-1 macrophages treated with MDP, v3 integrin blocking antibody incubation resulted in a dramatic reduction (reduced by 85%) of TNF production compared to control IgG-treated cells (Fig
