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Interestingly, NB-598 reduced intracellular ROS to similar levels as our positive control N-acetyl cysteine (N-Ac), which is commonly used as an antioxidant

CD38 is also responsible for the mitochondrial dysfunction by regulation of SIRT3 activity

doi:10.1056/NEJMoa2410027 10

This overview is intended to contextualize existing findings, without suggesting subtype-specific therapeutic applications (Table 1)

[7] There are three major families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel)