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Common side effects of GLP-1 medications, including semaglutide and tirzepatide, may include nausea, decreased appetite, mild digestive discomfort, and occasional changes in bowel habits
Glycine helps counteract that by supporting protein synthesis and antioxidant defense, helping the body maintain lean tissue through the process
Most major clinical trials for tirzepatide excluded patients taking other weight loss medications, making it difficult to assess the true benefit-to-risk ratio of combination therapy
One review looking at perimenopausal and postmenopausal women found that berberine may help lower LDL cholesterol, triglycerides and insulin resistance, and it might also help improve mood
The destroyed tissue may then be completely reabsorbed
